Journal
ANNALS OF NEUROLOGY
Volume 64, Issue 3, Pages 348-352Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.21446
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Funding
- MRC [G0701075] Funding Source: UKRI
- Medical Research Council [G0701075] Funding Source: researchfish
- Intramural NIH HHS [Z99 AG999999] Funding Source: Medline
- Medical Research Council [G0701075] Funding Source: Medline
- Parkinson's UK [G-0907] Funding Source: Medline
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We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.
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