Journal
ANNALS OF NEUROLOGY
Volume 63, Issue 6, Pages 790-793Publisher
WILEY
DOI: 10.1002/ana.21375
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Funding
- Multiple Sclerosis Society [748] Funding Source: Medline
- Wellcome Trust [074618/Z/04/Z, 064607] Funding Source: Medline
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Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.
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