Journal
AUTOPHAGY
Volume 2, Issue 3, Pages 241-243Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.2743
Keywords
HOG1; liver; p38(MAPK) rapamycin; starvation; proteolysis; tensegrity; macromolecular crowding; cell hydration
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The mechanisms of regulation of autophagy are still obscure. In mammalian liver, starvation-induced autophagic proteolysis is regulated by the cellular hydration state in a microtubule- and p38(MAPK)-dependent way. Recent work shows that in yeast, loss of Hog 1, the yeast orthologue of p38(MAPK), leads to osmosensitivity of starvation-induced autophagy (Prick et al., Biochem J 2006; 394:153-161), pointing to an evolutionarily conserved mechanism. In this addendum further experiments from hog 1 Delta yeast cells are shown, which support the hypothesis that starvation- and rapamycin-induced autophagy processes differ in their susceptibility to osmotic stress. The potential mechanisms are discussed.
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