Journal
JOURNAL OF BACTERIOLOGY
Volume 188, Issue 13, Pages 4996-5001Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00317-06
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Funding
- NIAID NIH HHS [R01 AI048935, R01 AI067737, 1R01AI067737-01, 1R01AI48935] Funding Source: Medline
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The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.
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