Journal
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
Volume 51, Issue 8, Pages 531-539Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/070674370605100808
Keywords
schizophrenia; substance use disorders; dual diagnosis; long-acting risperidone; zuclopenthixol
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Objective: This study aimed to compare the efficacy of long-acting risperidone and zuelopenthixol in subjects with schizophrenia and substance abuse. Method: A total of 115 subjects with schizophrenia and substance use disorders were enrolled for an open, randomized, controlled, 6-month follow-up study. Fifty-seven subjects were selected for treatment with long-acting injectable risperidone, while another 58 were treated with zuclopenthixol-depot. Results: Long-acting risperidone patients presented fewer positive urine tests (8.67 compared with 10.36, P = 0.005), showed improved scores on the Positive and Negative Syndrome Scale, and showed better compliance with the Substance Abuse Management program. The use of long-acting risperidone and less severe dependence. explained the outcome at the end of the follow-up. Conclusions: Long-acting injectable risperidone was more effective than zuclopenthixol-depot in improving substance abuse and schizophrenia symptoms in subjects with dual diagnosis.
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