Journal
EUROPEAN CELLS & MATERIALS
Volume 12, Issue -, Pages 92-101Publisher
SWISS SOCIETY FOR BIOMATERIALS, AO RESEARCH INSTITUTE
DOI: 10.22203/eCM.v012a11
Keywords
proteoglycan; aggrecan; link protein; hyaluronan; decorin; biglycan; fibromodulin; lumican; cartilage
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Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains. This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function.
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