Journal
MAGNETIC RESONANCE IN CHEMISTRY
Volume 44, Issue -, Pages S24-S40Publisher
WILEY
DOI: 10.1002/mrc.1816
Keywords
NMR; membrane; proteins; solution; review; detergent; detergents; micelles; amphipols; lipopeptides; bicelles; TROSY; labeling; deuteration; structure; backbone; fold
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This review focuses upon the application of solution NMR methods to multispan integral membrane proteins, particularly with respect to determination of global folds by this approach. Practical methods are described along with the special difficulties that confront the application of solution NMR to proteins that dwell in the netherworld of the lipid bilayer. Copyright (C) 2006 John Wiley & Sons, Ltd.
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