Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 7, Pages 473-483Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1960
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Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains. We propose that these domains, working together, read the state of the proteome and therefore couple post-translational modifications to cellular organization. We also identify common strategies through which modification-dependent interactions synergize to regulate cell behaviour.
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