Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim™) or a bovine-derived xenograft (Bio-Oss™) in combination with a collagen membrane (Bio-Gide™).: A case series

Objectives: The aim of the present case series was to evaluate the healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (NHA) or a bovine-derived xenograft in combination with a collagen membrane (BDX+BG). Material and Methods: Twenty-two patients having moderate peri-implantitis (n=22 intrabony defects) were randomly treated with (i) access flap surgery (AFS) and the application of NHA, or with AFS and the application of BDX+BG. Clinical parameters were recorded at baseline and after 6 months of non-submerged healing. Results: Post-operative wound healing revealed that NHA compromized initial adhesion of the mucoperiosteal flaps in all patients. At 6 months after therapy, NHA showed a reduction in the mean PD from 7.0 +/- 0.6 to 4.9 +/- 0.6 mm and a change in the mean clinical attachment loss (CAL) from 7.5 +/- 0.8 to 5.7 +/- 1.0 mm. In the BDX+BC group, the mean PD was reduced from 7.1 +/- 0.8 to 4.5 +/- 0.7 mm and the mean CAL changed from 7.5 +/- 1.0 to 5.2 +/- 0.8 mm. Conclusion: Within the limits of the present case series, it can be concluded that at 6 months after surgery both therapies resulted in clinically important PD reductions and CAL gains.