Journal
CELL CYCLE
Volume 5, Issue 13, Pages 1361-1365Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.13.2891
Keywords
chromatin; histones; post-translational modifications; acetylation; euchromatin; transcription
Categories
Funding
- NIGMS NIH HHS [GM54096] Funding Source: Medline
Ask authors/readers for more resources
How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available