Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 16, Issue 5, Pages 146-152Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2006.03.002
Keywords
-
Categories
Funding
- NHLBI NIH HHS [R01 HL 73852, R01 HL 57506] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 55656] Funding Source: Medline
Ask authors/readers for more resources
The precise signals responsible for differentiation of circulating monocytes into tissue macrophages are incompletely defined. Outside-in integrin signaling has been implicated in modulating gene expression that affects cellular differentiation. This review highlights the role of transcription factors in monocyte differentiation and describes how integrin engagement orchestrates monocyte differentiation signals by regulating the expression of the forkhead transcription factor Foxp1, which functions as a transcriptional repressor of the macrophage colony-stimulating factor receptor c-fms. This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available