Journal
DEVELOPMENTAL DYNAMICS
Volume 235, Issue 7, Pages 1753-1760Publisher
WILEY
DOI: 10.1002/dvdy.20814
Keywords
blood vessels; zebrafish; fused somites; beamter; deltaC
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NHLBI NIH HHS [R01 HL092263] Funding Source: Medline
Ask authors/readers for more resources
We identified four mutants in two distinct loci exhibiting similar trunk vascular patterning defects in an F3 genetic screen for zebrafish vascular mutants. Initial vasculogenesis is not affected in these mutants, with proper specification and differentiation of endothelial cells. However, all four display severe defects in the growth and patterning of angiogenic vessels in the trunk, with ectopic branching and disoriented migration of intersegmental vessels. The four mutants are allelic to previously characterized mutants at the fused-somites (fss) and beamter (bea) loci, and they exhibit comparable defects in trunk somite boundary formation. The fss locus has been shown to correspond to tbx24; we show here that bea mutants are defective in the zebrafish dlC gene. Somitic expression of known vascular guidance factors efnb2a, sema3a1, and sema3a2 is aberrantly patterned in fss and bea mutants, suggesting that the vascular phenotype is due to loss of proper guidance cues provided by these factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available