4.3 Article

Chemical constituents from the endophytic fungus Trichoderma ovalisporum isolated from Panax notoginseng

Journal

ANNALS OF MICROBIOLOGY
Volume 60, Issue 2, Pages 317-320

Publisher

SPRINGER
DOI: 10.1007/s13213-010-0043-2

Keywords

Trichoderma ovalisporum; Panax notoginseng; Endophyte; ITS sequence; Antimicrobial compounds

Funding

  1. National Basic Research Program of China (973 Program) [2007CB411600]
  2. National Natural Science Foundation of China [30960007]
  3. Natural Science Foundation of Yunnan Province [2007B156M]

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Strain PRE-5 was isolated from the root of the herbal plant Panax notoginseng and was identified as Trichoderma ovalisporum based on its sequence at the internal transcribed spacer (ITS) regions. From the extracts of fermentation broth and mycelia of strain PRE-5, five compounds koninginin A (1), (E)-2,3-dihydroxypropyl octadec-9-enoate (2), shikimic acid (3), adenine ribonucleoside (4), and cytosine ribonucleoside (5) were obtained. Their structures were elucidated on the basis of their spectroscopic data. All compounds were assayed for antibacterial activity. Compound 3 showed activity against Staphylococcus aureus, Bacillus cereus, Micrococcus luteus and Escherichia coli.

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