4.6 Article

Nicotine replacement therapy - Patterns of use after a quit attempt among methadone-maintained smokers

Journal

JOURNAL OF GENERAL INTERNAL MEDICINE
Volume 21, Issue 7, Pages 753-757

Publisher

BLACKWELL PUBLISHING
DOI: 10.1111/j.1525-1497.2006.00504.x

Keywords

methadone maintenance; clinical trial; nicotine replacement; adherence

Funding

  1. NCI NIH HHS [R01 CA084392, R01 CA84392] Funding Source: Medline
  2. NIDA NIH HHS [K24 DA00512, K24 DA000512] Funding Source: Medline

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AIM; To determine the association between daily smoking and use of nicotine replacement therapy (NRT), and to determine predictors of greater NRT use among methadone-maintained smokers. INTERVENTION: Assignment to free nicotine patch (8 to 12 weeks) plus either (1) a baseline-tailored brief motivational intervention, a quit date behavioral skills counseling session, and a relapse prevention follow-up session (max), or (2) brief advice using NCI's 4 A's model (min). SETTING: Five methadone maintenance treatment centers. PARTICIPANTS: Of the 383 methadone-maintained smokers enrolled, 309 (80.6%) set a specific quit date (received NRT) and were located for assessments. Participants were 51.8% male, 78.6% Caucasian, and smoked 26.6 (SD = 12.2) cigarettes/day. OUTCOME: Use of NRT and smoking behaviors during the 180-day follow-up period assessed by the Timeline follow-back method. FINDINGS: On the day following their quit day, 86.4% of participants used NRT. The percentage of participants using NRT was 52.3%, 27.1%, and 10.4% on day 30, day 60, and day 90, respectively. Participants used NRT on 44.1% of the days through the 90 days of the treatment protocol. The estimated odds of smoking abstinence was 7.1 (P < .001) times higher on days when NRT was used than on days when NRT was not used, and cigarettes/day was also significantly lower on NRT days (14.93 vs 4.65; P < .001). CONCLUSION: Nicotine replacement therapy use was inconsistent following an initial quit attempt among methadone-maintained smokers. On days when NRT was used, individuals were likely to smoke at reduced levels or not at all.

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