Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 13, Pages 3459-3462Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.04.011
Keywords
HIV protease inhibitor; lysine; amino acids; resistant viral strains
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A series of lysine sulfonamide analogues bearing N epsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses. (c) 2006 Elsevier Ltd. All rights reserved.
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