In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

The activity of linezolid was studied against 55 Mycobacterium tuberculosis (42 susceptible, 3 isoniazid resistant and 10 isoniazid and rifampicin resistant), one Mycobacterium bovis and two multidrug-resistant M. bovis isolates using the standard 7H10 agar proportion and the ESP Culture System 11 methods. Both methods displayed similar MIC90 values (minimum inhibitory concentrations for 90% of the organisms) of 0.5 mg/L; however, the former method yielded slightly lower MIC50 values (MICs for 50% of the organisms) (0.25 mg/L) compared with the latter method (0.5 mg/L). No differences were observed between susceptible and resistant isolates, including multidrug-resistant M. bovis isolates, with a MIC range of 0.12-0.5 mg/L. The potential role of linezolid in tuberculosis patients requires further in vivo evaluation. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.