Journal
ANNALS OF MEDICINE
Volume 50, Issue 7, Pages 576-586Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890.2018.1523549
Keywords
TyG index; HGI; T2DM; stable CAD; outcomes
Categories
Funding
- Capital Health Development Fund [201614035]
- CAMS Major Collaborative Innovation Project [2016-I2M-1-011]
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Aim: Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined.Methods: We conducted a nested case-control study among 1282 T2DM patients with stable CAD. Patients were followed up for 3846 person-years. A total of 160 patients with events (12.5%) were identified and matched individually on age, gender, previous use of lipid lowering agents and duration of follow-up with 640 controls.Results: In Kaplan-Meier analysis, the upper tertiles of TyG index and HGI had a significant lower event-free survival (p=.002; p=.036, respectively). Of the note, both TyG index and HGI were associated with increased risk of MACCEs after adjusting for confounding risk factors [adjusted HR (95% CI): 1.693 (1.238-2.316); 1.215 (1.046-1.411), respectively]. Moreover, adding TyG index to the Cox model increased the C-statistic to 0.638 (95%CI: 0.595-0.683, p=.002) while the C-statistic was not statistically improved when HGI was included (p=.240).Conclusions: Both TyG index and HGI could predict cardiovascular outcomes in T2DM patients with new-onset, stable CAD while TyG index might be better.
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