Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 22, Issue 1, Pages 40-45Publisher
ELSEVIER
DOI: 10.1016/j.etap.2005.11.008
Keywords
pesticide; organophosphate; electrocardiogram; QT; arrhythmia; aerial spray
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The relation between the electrocardiographic manifestation and the subjective symptoms accompanying organophosphate pesticide exposure caused by aerial spray was investigated. The study included 39 patients with a diagnosis of organophosphate poisoning, who visited A-clinic within 24 h of exposure to aerial spray of organophosphate pesticide in Gumma Prefecture, from July 2001 to September 2001. Ages ranged from 3 to 82 years. Thirty-five patients were female. Three were diagnosed as severe, 11 moderate, and 25 mild, judged from the score of subjective symptoms. Electrocardiographic abnormalities were bradycardia (< 50) 2; prolonged PQ interval 4; prolonged QTc interval (> 430 ms) 22; nonspecific ST-T change 35; supraventricular arrhythmia 13; and ventricular premature complex with R on T 1. Prolonged QTc interval developed in 2-3 severe cases, 4-11 moderate cases, and 16-25 mild cases. QT prolongation, ST-T change and arrhythmia were detected for some patients exposed to organophosphate by aerial spray. (c) 2005 Elsevier B.V. All rights reserved.
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