Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 32, Issue 3, Pages 139-153Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10408410600822942
Keywords
protein; S. pneumoniae; vaccine
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Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.
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