Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 97, Issue 1, Pages 18-25Publisher
ELSEVIER SCI LTD
DOI: 10.1093/bja/ael109
Keywords
brain, injury; metabolism, metabolites; monitoring, intensive care; monitoring, microdialysis
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Funding
- Wellcome Trust [075608] Funding Source: Medline
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Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a bedside monitor to provide on-line analysis of brain tissue biochemistry during neurointensive care. This review describes the principles of cerebral microdialysis and the rationale for its use in the clinical setting, including discussion of the most commonly used microdialysis biomarkers of acute brain injury. Potential clinical applications are reviewed and future research applications identified. Microdialysis has the potential to become an established part of mainstream multi-modality monitoring during the management of acute brain injury but at present should be considered a research tool for use in specialist centres.
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