Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 11, Issue 4, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2337290
Keywords
biophotoacoustics; biomedical optics; imaging systems; thermo-optics; Fourier transforms; tissue
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A novel photothermoacoustic imaging modality utilizing a frequency-swept (chirped) intensity-modulated laser source and coherent frequency domain signal processing (biophotoacoustics) was introduced for noninvasive imaging of biological tissues. The developed frequency-domain imaging system takes advantage of linear frequency modulation waveforms to relate depth of tissue chromophores to the frequency spectrum of the detected acoustic response and of a narrow signal detection bandwidth to improve signal-to-noise ratio (SNR). Application of frequency-domain photothermoacoustic (FD-PTA) imaging was demonstrated using turbid phantoms and ex-vivo specimens of chicken breast with embedded absorbing inclusions simulating tumors. (c) 2006 Society of Photo-Optical Instrumentation Engineers.
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