Journal
ANNALS OF MEDICINE
Volume 43, Issue 1, Pages 1-12Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07853890.2010.538078
Keywords
Circadian; gene expression; oscillation
Categories
Ask authors/readers for more resources
Multiple microarray studies have documented the importance of circadian regulation of gene expression in different species under many experimental conditions. However, these reports often differ with respect to the identity and total number of oscillating genes. This review explores the interrelated questions of: How many genes are oscillating within individual tissues or systems? What are the forces that drive these oscillations? What are the methodological sources contributing to the discrepancy between estimates of gene oscillation? And finally, what are the physiological and systemic implications of oscillatory gene expression with respect to circadian molecular biology? Since this remains an evolving area of investigation, this hypothetical and speculative review also highlights the potential limitations faced by the current data in the literature relating to the novel paradigm(s) proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available