Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 26, Issue 14, Pages 5325-5335Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00584-06
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Chromatin is considered to be a principal carrier of epigenetic information due to the ability of alternative chromatin states to persist through generations of cell divisions and to spread on DNA. Replacement histone variants are novel candidates for epigenetic marking of chromatin. We developed a novel approach to analyze the chromatin environment of nucleosomes containing a particular replacement histone. We applied it to human H2AZ, one of the most studied alternative histories. We find that neither H2AZ itself nor other features of the H2AZ-containing nucleosome spread to the neighboring nucleosomes in vivo. arguing against a role for H2AZ as a self-perpetuating epigenetic mark.
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