Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 385, Issue 6, Pages 1082-1086Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-006-0506-2
Keywords
volatile residual solvents; HS-LPME; flame ionization detector; pharmaceutical products
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This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-2.0 mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
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