Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 13, Issue 7, Pages 661-662Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1114
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Funding
- NCI NIH HHS [Y1-CO-1020] Funding Source: Medline
- NIDDK NIH HHS [P30 DK056341-06, P30 DK056341] Funding Source: Medline
- NIGMS NIH HHS [Y1-GM-1104] Funding Source: Medline
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Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD(+) biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
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