Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 118, Issue 1, Pages 214-219Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2006.05.004
Keywords
atopic dermatitis; skin barrier; epidermal differentiation complex; polymorphisms; filaggrin
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Funding
- Medical Research Council [G0700314] Funding Source: Medline
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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic background. One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation. Objectives: Recently, 2 loss-of-function mutations (R501X and 2282der14) in the filaggrin gene (FLG) that cause ichthyosis vulgaris, one of the most common inherited skin disorders of keratinization, have been reported to be strong predisposing factors for AD.
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