Journal
TRENDS IN GENETICS
Volume 22, Issue 7, Pages 354-357Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2006.04.009
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Early studies suggested that proteins with a greater contribution to the fitness of an organism evolve more slowly than less 'important' proteins. Recent articles by two research groups highlight the long-standing controversy about the genome-wide relationships between the measures of evolution rate, protein abundance and the fitness effect of gene disruption. These studies highlight the need for truly multidimensional approaches to the issues of quantitative genomics.
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