Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 17, Issue 5, Pages 186-191Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2006.04.002
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- NIDDK NIH HHS [DK73466] Funding Source: Medline
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Sirtuins (Sir2-related enzymes) are a recently discovered class of NAD+-dependent protein deacetylases that regulate gene expression in a variety of organisms by deacetylation of modified lysine residues on histones, transcription factors and other proteins. Conservation of sirtuin regulation of the insulin-insulin-li*ke growth factor I signaling pathway has been observed for Caenorhabditis elegans and mammals, indicating an ancient role for sirtuins in the modulation of organism adaptations to nutritional intake. The human sirtuin SIRT1 regulates a number of transcription factors that modulate endocrine signaling, including peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma coactivator la, forkhead-box transcription factors and p53.
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