Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 27, Pages 10300-10304Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0602234103
Keywords
slug; development; evolution
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Funding
- NCI NIH HHS [P30 CA034196, CA034196] Funding Source: Medline
- NICHD NIH HHS [HD034883, R01 HD034883] Funding Source: Medline
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Snail family genes encode zinc finger transcriptional repressors that are key regulators of epithelial-mesenchymal transitions in vertebrates, including the transitions that generate the mesoderm and neural crest. Here, we show that, contrary to observations in frog and avian embryos, the Snail family genes Snail (Snail) and Slug (Snail) are not required for formation and delamination of the neural crest in mice. However, embryos with conditional inactivation of Snail function exhibit defects in left-right asymmetry determination. This work demonstrates that although some aspects of Snail family gene function, such as a role in left-right asymmetry determination, appear to be evolutionarily conserved, their role in neural crest cell formation and delamination is not.
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