Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 14, Pages 5357-5360Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo060018d
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Funding
- NCRR NIH HHS [P20 RR 16455-04] Funding Source: Medline
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Berkeley Pit Lake is an abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive metabolites. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known gamma-pyrone, spiciferone A 4. Berkelic acid has shown selective, nanomolar activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. The isolation and characterization of these compounds are reported here.
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