Journal
JOURNAL OF PROTEOME RESEARCH
Volume 5, Issue 7, Pages 1701-1710Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr060101h
Keywords
hormone-sensitive lipase; white adipose tissue; proteomics; retinoic acid; inflammation
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In the present study, a local inflammatory response in white adipose tissue from the nonobese HSL-null mouse model is demonstrated. The protein levels of several well-known markers of inflammation, like TNF alpha and ferritin HC, were highly increased and accompanied by an activation of NF kappa B. A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells.
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