Journal
NEUROLOGY
Volume 67, Issue 1, Pages 33-38Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000230572.07791.22
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Funding
- NIMH NIH HHS [R01 MH062539, R01 MH62539] Funding Source: Medline
- NINDS NIH HHS [K23 NS044997-01A1, F31 NS059142-01A1, F31 NS059142-02, K23 NS044997, R01 NS050633, R01 NS50633] Funding Source: Medline
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Objective: To examine the hypothesis that apathy is a core feature of Parkinson disease (PD) and that apathy can be dissociated from depression. Methods: Eighty patients with PD and 20 patients with dystonia completed depression and apathy measures including the Marin Apathy Evaluation Scale (AES), Beck Depression Inventory (BDI), and Centers for Epidemiologic Studies-Depression Scale (CES- D). Results: There was a significantly higher severity and frequency of apathy in PD (frequency = 51%, 41/80) than in dystonia (frequency = 20%, 4/20). Apathy in the absence of depression was frequent in PD and did not occur in dystonia (PD = 28.8%, dystonia = 0%). Conclusions: Patients with Parkinson disease (PD) experienced significantly higher frequency and severity of apathy when compared with patients with dystonia. Apathy may be a core feature of PD and occurs in the absence of depression.
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