Journal
NANO LETTERS
Volume 6, Issue 7, Pages 1459-1463Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl060765q
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Funding
- Intramural NIH HHS Funding Source: Medline
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A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.
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