Journal
SYNLETT
Volume -, Issue 11, Pages 1771-1773Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-944210
Keywords
dihydroxylation; hydrogenation; coupling; reboxetine; trans-cinnamyl bromide
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An efficient enantioselective synthesis leading directly to (+)-(S,S)-reboxetine has been described from commercially available trans-cinnammyl bromide using Sharpless asymmetric dihydroxylation as the key step.
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