Journal
JOURNAL OF PHYSICAL CHEMISTRY A
Volume 110, Issue 27, Pages 8282-8296Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp055426k
Keywords
-
Ask authors/readers for more resources
The fragmentation pathways of protonated arginine, protonated N-alpha, N-alpha-dimethylarginine, the N-alpha, N-alpha, N-alpha-trimethylarginine ion, three protonated N-is an element of, N-is an element of-dimethyllysines, and three permanent lysine ions in which the charge is fixed by trimethylation are reported. Ion assignment was facilitated by N-15-labeling and deuterium substitution. The chemistries are dominated by charge-induced elimination of the amino groups as neutrals, including dimethylamine, trimethylamine and guanidine. Competitive losses of the alpha-amino and side- chain amino groups were observed; these losses led to intermediates that had different structures and different subsequent dissociation reactions. Concomitant losses of CO or CO2 with these amines were also commonly observed. However, the ionic products of amine losses did not subsequently lose CO or CO2, suggesting strongly that in these concomitant eliminations, it is the CO or CO2 that was first eliminated, followed immediately by the loss of the amine. Results of density functional theory calculations on protonated arginine and protonated N-alpha,N-alpha-dimethylarginine reveal that, in such concomitant eliminations, the dissociating complex is vibrationally hot and the intermediate ion formed by losing CO or CO2 can immediately dissociate to eliminate the amine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available