Journal
NATURE
Volume 442, Issue 7099, Pages 153-158Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature04885
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- NIGMS NIH HHS [R01 GM058673] Funding Source: Medline
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During meiosis, accurate separation of maternal and paternal chromosomes requires that they first be connected to one another through homologous recombination. Meiotic recombination has many intriguing but poorly understood features that distinguish it from recombination in mitotically dividing cells, and several of these features depend on the meiosis-specific DNA strand exchange protein Dmc1 ( disrupted meiotic cDNA1). Many questions about this protein have arisen since its discovery more than a decade ago, but recent genetic and biochemical breakthroughs promise to shed light on the unique behaviours and functions of this central player in the remarkable chromosome dynamics of meiosis.
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