Journal
NANOTECHNOLOGY
Volume 17, Issue 13, Pages 3268-3273Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/17/13/032
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CdTe-coated magnetic polystyrene nanospheres (MPN) were prepared via a stepwise electrostatic self-assembly approach, and the conjugation of epidermal growth factor (EGF) to the MPN/CdTe core - shell nanocomposites was prepared by using 1-ethyl-3(3-dimethylamino propyl)- carbodiimide (EDC) as a cross-linking reagent. The MPN/CdTe and their bioconjugates yielded not only emitted bright fluorescence, but also exhibited superparamagnetism. The human breast cancer MDA-MB-435S cells could be labelled and rapidly separated by the MPN/CdTe - EGF bioconjugates. These magnetofluorescent nanospheres, consisting of magnetic spheres and quantum dots (QDs), may be of special interest for many biomedical applications.
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