Journal
GENES & DEVELOPMENT
Volume 20, Issue 14, Pages 1880-1884Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.379706
Keywords
geminin; endoreduplication; trophoblast; Oct4; Cdx2; pluripotency
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M100] Funding Source: Medline
- Medical Research Council [G120/824, MC_U105359878] Funding Source: Medline
- MRC [G120/824, MC_U105359878] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M100] Funding Source: researchfish
- Medical Research Council [MC_U105359878, G120/824] Funding Source: researchfish
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In multicellular eukaryotes, geminin prevents overreplication of DNA in proliferating cells. Here, we show that genetic ablation of geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells. All cells in geminin-deficient embryos commit to the trophoblast cell lineage and consist of trophoblast giant cells (TGCs) only. Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication.
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