Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 14, Pages 3864-3867Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.04.034
Keywords
quinolones; Sparfloxacin; Cu(II) complex; EPR spectroscopy; interaction with calf-thymus DNA; MIC
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The neutral mononuclear copper(II) complex with the quinolone antibacterial drug sparfloxacin has been prepared and characterized with 1R, UV-vis, and EPR spectroscopies and X-ray crystallography. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms. (c) 2006 Elsevier Ltd. All rights reserved.
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