Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 2, Pages 777-781Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.2.777
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Funding
- NIAID NIH HHS [R37 AI 21372, R37 AI021372-22, R37 AI021372, R01 AI 37988, R01 AI037988] Funding Source: Medline
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Factors that influence T cell responses, such as Ag load, APCs, costimulatory molecules, and cytokines, dramatically change during the course of an immune response. We observed that antiviral CD8 T cells were not recruited from circulation simultaneously, but over a period of 3-4 days. Consequently, locally resident T cells and those that entered-secondary lymphoid tissue later were primed 171 very different environments. The cells recruited later in the response were imprinted with a unique differentiation program, such that their magnitude of proliferation was reduced and their kinetics of expansion was delayed. In addition, we found that the latecomer CD8 T cells displayed a unique surface phenotype indicative of reduced stimulation but were not preferentially recruited into the surviving pool of memory cells. This finding demonstrates that the timing of recruitment of individual T cell clones determines the population dynamics of the subsequent immune response.
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