Journal
CARDIOVASCULAR RESEARCH
Volume 71, Issue 2, Pages 216-225Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2006.02.033
Keywords
oxygen radicals; NADPH oxidase; signal transduction; smooth muscle
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Funding
- NHLBI NIH HHS [HL 58863, HL 58000, P01 HL058000, R01 HL058863, R37 HL038206, P01 HL075209, HL 38206, R01 HL073101, HL 75209, R01 HL038206] Funding Source: Medline
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Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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