Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 2, Pages 831-839Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.2.831
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Funding
- NIAID NIH HHS [AI 30048, AI 044644] Funding Source: Medline
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Heterologous prime-boost vaccination results in increased frequencies of memory T cells. Although these quantitative effects of reexposure to Ag are well documented, little is known about the impact of boosting on the functional qualities of memory T cells. To address this critical issue, we have used three different types of immunization regimens and examined how boosting effects the function and anatomic location of memory CD8 T cells. We found that memory T cell phenotype differed substantially depending on the number of immunizations and that secondary and tertiary responses resulted in the generation of memory CD8 T cells that retained effector-like properties and showed preferential accumulation in nonlymphoid tissues. These results show that memory differentiation is coupled to the history of Ag experience and that prime-boost vaccination strategies have important consequences on memory CD8 T cell quality and surveillance within mucosal tissues.
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