Journal
CARDIOVASCULAR RESEARCH
Volume 71, Issue 2, Pages 259-268Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2006.03.002
Keywords
atherosclerosis; oxygen radicals
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There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
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