Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 155, Issue 1, Pages 28-38Publisher
ELSEVIER
DOI: 10.1016/j.jneumeth.2005.12.032
Keywords
ensemble recording; microdrive; stereotrode; tetrode; hippocampus; memory; startle; in vivo recording; CA1 region; mouse
Categories
Ask authors/readers for more resources
With the availability of sophisticated genetic techniques, the mouse is a valuable mammalian model to study the molecular and cellular basis of cognitive behaviors. However, the small size of mice makes it difficult for a systematic investigation of activity patterns of neural networks in vivo. Here we report the development and construction of a high-density ensemble recording array with up to 128-recording channels that can be formatted as single electrodes, stereotrodes, or tetrodes. This high-density recording array is capable of recording from hundreds of individual neurons simultaneously in the hippocampus of the freely behaving mice. This large-scale in vivo ensemble recording techniques, once coupled with mouse genetics, should be valuable to the study of complex relationship between the genes, neural network, and cognitive behaviors. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available