4.6 Article

Antimicrobial activity of statistical polymethacrylic sulfopropylbetaines against gram-positive and gram-negative bacteria

Journal

JOURNAL OF APPLIED POLYMER SCIENCE
Volume 101, Issue 2, Pages 1036-1041

Publisher

WILEY
DOI: 10.1002/app.23269

Keywords

biological applications of polymers; copolymerization; radical polymerization; structure-property relations

Ask authors/readers for more resources

A series of statistical copolymers derived from 2-(dimethylamino)ethyl methacrylate with four different hydrophobic comonomers (ethyl, butyl, cyclohexyl, and octyl methacrylates) have been prepared via conventional free radical copolymerization under bulk conditions. The copolymers have been subsequently modified, with 1,3-propanesultone to yield the corresponding polysulfoproylbetaine derivatives. Those copolymers exhibiting the requisite aqueous solubility have been screened with respect to their antimicrobial activity against two common and notorious pathogens, namely Staphylococciis aureus (S. aureus) and Escherichia coli (E. coli). We show that certain copolymers do indeed exhibit antimicrobial activity. The extent of activity is related to the molecular characteristics of the materials such as the molar composition and structure of the hydrophobic comonomer. (c) 2006 Wiley Periodicals, Inc.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available