Journal
TETRAHEDRON-ASYMMETRY
Volume 17, Issue 11, Pages 1754-1757Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2006.06.019
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The Schollkopf methodology for the asymmetric synthesis of alpha-amino acids which was previously not applicable to the construction of alpha,alpha-dialkylated (quaternary) alpha-amino acids, has been rendered practical for this purpose and applied in a highly efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377. (c) 2006 Elsevier Ltd. All rights reserved.
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