4.4 Article

An economic and practical synthesis of the 2-tetrahydrofuranyl ether protective group

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 29, Pages 5111-5113

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.05.081

Keywords

protecting group; manganese; radical reaction; tetrahydrofuran

Funding

  1. NIDDK NIH HHS [P01 DK038226-190006, P01 DK038226] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM031278-22, R01 GM031278] Funding Source: Medline

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Primary, secondary, and tertiary alcohols as well as phenols and carbohydrates are efficiently transformed into the corresponding 2-tetrahydrofuranyl ethers by a combination of Mn(0) powder and CCl4 in tetrahydrofuran. (c) 2006 Elsevier Ltd. All rights reserved.

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