Journal
ORGANIC LETTERS
Volume 8, Issue 15, Pages 3191-3194Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol060916w
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- NIGMS NIH HHS [GM 60600] Funding Source: Medline
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Cultures of the freshwater aquatic fungus Helicodendron giganteum afforded three new compounds, heliconols A-C (1-3), that contain an unusual reduced furanocyclopentane unit. The structures of these metabolites were assigned by analysis of 1D and 2D NMR data. The absolute configuration of heliconol A ( 1) was assigned by single-crystal X-ray crystallographic analysis of its dibromobenzoate derivative. Heliconol A showed antifungal and antibacterial activities in disk diffusion assays.
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