4.7 Article

An expeditious enantioselective total synthesis of valilactone

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 15, Pages 5748-5751

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo060844m

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The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic centers and a hydroxyl group activation (HGA) protocol to construct the anti alpha,beta-disubstituted beta-lactone from the corresponding syn aldol.

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