Constant supersaturation control of antisolvent-addition batch crystallization

We have developed a simple method to design antisolvent-addition crystallization by using a numerical simulation. To design the reasonable conditions, e. g. the profile of antisolvent addition, seed loading, and minimum time cycle, a numerical simulation was applied using kinetic parameters obtained from experiments. ReactIR was used for on-line monitoring, which enabled the concentration, supersaturation, and growth rate to be monitored throughout the crystallization process. This model takes into account only growth and ignores nucleation, agglomeration, and breakage. The results of the numerical simulations agreed well with the corresponding experimental results and assisted in the design of a suitable crystallization process.